The many books that have been written on bioinformatics tend to fall on two extremes: books that feature computational details with a great deal of mathematics, for computational scientists and mathematicians, or books that treat bioinformatics mostly as a giant black box, for biologists. Previous books written on bioinformatics often have limited contribution to creating interdisciplinary scientists needed in modern biological and biomedical sciences. This book aims to render both mathematical equations and biology to numbers, to help truly interdisciplinary scientists. Although the book covers bioinformatics methods at a level more advanced than most other bioinformatics books, the extensive numerical illustration of these methods should make it accessible to most senior undergraduate students and graduate students majoring in science and software engineering. Nearly all algorithms in the book are implemented in a free and user-friendly computer program (DAMBE).